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現貨moradec AM-106-PB說明書
αMFc CL PBD
具有可裂解連接子的抗小鼠IgG Fc PBD抗體
目錄號:AM-106-PB
αMFc CL PBD是抗小鼠IgG Fc特異性抗體,與吡咯并二氮雜平(PBD)結合,具有可裂解接頭。抗體部分是對小鼠IgG的Fc區具有特異性的多克隆抗體,并且它也對大鼠IgG的Fc區具有交叉反應性。吡咯并二氮卓(PBD)是一種細胞毒性小分子,它與DNA小凹槽結合,并與DNA的特定位點交叉連接。連接PBD和抗體的可裂解接頭在細胞外液中是穩定的,但一旦綴合物通過內吞作用進入細胞,就會被內體中的組織蛋白酶裂解。



| Anti-Mouse IgG Fc-PBD Antibody with Cleavable Linker | Catalog Number: AM-106-PB |
| αMFc-CL-PBD is anti-mouse IgG Fc specific antibody conjugated to pyrrolobenzodiazepine (PBD) with a cleavable linker. The antibody portion is a polyclonal antibody which is specific to the Fc region of mouse IgGs, and it is also cross-reactive to the Fc region of Rat IgGs. Pyrrolobenzodiazepine (PBD) is a cytotoxic small molecule which binds to DNA minor groove and cross-links specific sites of DNA. The cleavable linker connecting PBD to the antibody is stable in extracellular fluid, but is cleaved by cathepsin in endosome once the conjugate has entered a cell via endocytosis. | |